2025-11-05
Magnesium in Bone Repair and Immune Modulation
🧠 Magnesium and Bone Regeneration — Where Material Science Meets Immunology
The immune system plays a crucial role in bone healing — regulating inflammation, promoting angiogenesis, and balancing osteoblast and osteoclast activity.
Recent studies have revealed that magnesium ions (Mg²⁺) not only support bone mineralization but also modulate the immune microenvironment, guiding bone regeneration through complex biological signaling.
Research led by Prof. Qin Ling (Nature Medicine, 2016) and Prof. Kelvin Yeung (Nature Communications) demonstrated how magnesium-induced TRPM7 and NF-κB signaling pathways influence macrophage activity — achieving early-stage osteoimmunomodulation while requiring precise Mg²⁺ control during remodeling.
Further studies published in Small highlighted the Mg²⁺–HIF-1α–TGF-β axis, showing how magnesium drives dendritic cell polarization and Treg formation, creating a favorable immune environment for bone healing.
💡 Clinically, the magnesium-containing bone repair material “Bogle®” (China NMPA Class III Innovation Device) has shown outstanding performance — 40% faster fusion at 12 weeks and 100% bone union at 24 weeks, attributed to controlled Mg²⁺ release and osteoimmune regulation.
At Tangshan Weihao Magnesium Powder Co., Ltd., we’re proud to supply high-purity atomized spherical magnesium powder for such pioneering medical materials.
Its uniform particle size, excellent biocompatibility, and spherical morphology ensure optimal performance in additive manufacturing and bioactive implants.
✨ Magnesium-based biomaterials are redefining the future of orthopedic implants and regenerative medicine — and we’re honored to be part of this transformation.
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